Year: 2021
Type: article
Abstract: Rationale: Surface enhanced Raman scattering (SERS) is proving to be a useful tool for biomedical imaging.However, this imaging technique can suffer from poor signal-to-noise ratio, as the complexity of biological tissues can lead to overlapping of Raman bands from tissues and the Raman reporter molecule utilized.Methods: Herein we describe the synthesis of triple bond containing Raman reporters that scatter light in the biological silent window, between 1750 cm -1 and 2750 cm -1 .Results: Our SERS nanoprobes are comprised of uniquely designed Raman reporters containing either alkyne-or cyano-functional groups, enabling them to be readily distinguished from background biological tissue.Conclusion: We identify promising candidates that eventually can be moved forward as Raman reporters in SERS nanoparticles for highly specific contrast-enhanced Raman-based disease or analyte detection in biological applications.
Source: Nanotheranostics
DOI: 10.7150/ntno.58965
Language: English
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $668
OpenAlex ID: W4200279919