Work

Author response: Molecular pathology of the R117H cystic fibrosis mutation is explained by loss of a hydrogen bond

Year: 2021

Type: peer-review

Abstract: The striking reduction in open probability of CFTR channels harboring the R117H cystic fibrosis mutation is caused by loss of a strong hydrogen bond between positions 117 and 1124, which is formed in wild-type channels selectively in the open state.

Source: eLife

DOI: 10.7554/elife.74693.sa2

Authors: Márton A Simon, László Csanády

Institution: Semmelweis University

Language: English

Topic: Cystic Fibrosis Research Advances

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

OpenAlex ID: W4200298715

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