Work

Progressive nodular histiocytosis in a 9‐year‐old boy treated with cobimetinib

Year: 2021

Type: article

Abstract: Progressive nodular histiocytosis is a rare variant of non-Langerhans cell histiocytosis that affects the skin and mucous membranes and displays a progressive clinical course and poor response to treatment. We describe a case of severe progressive nodular histiocytosis harboring a KRAS p.G12S mutation in a 9-year-old boy, refractory to chemotherapy, who was successfully treated with the MEK inhibitor cobimetinib. This is the first report of the use of MEK inhibition for this histiocytosis subtype in a pediatric patient.

Source: Pediatric Dermatology

DOI: 10.1111/pde.14887

Authors: María Marta Buján, Cristian Sánchez La Rosa, María Laura Galluzzo Mutti, Jorge Braier, Eli L. Diamond

Institutions: Garrahan Hospital, Memorial Sloan Kettering Cancer Center

Language: English

Topic: Histiocytic Disorders and Treatments

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute