Work

Epstein-Barr Virus miR-BHRF1-3 Targets the BZLF1 3’UTR and Regulates the Lytic Cycle

Year: 2021

Type: article

Abstract: Epstein-Barr virus infection is predominantly latent in healthy individuals, while periodic cycles of reactivation are thought to facilitate persistent lifelong infection. Lytic infection has been linked to development of certain EBV-associated diseases. Here, we demonstrate that EBV miR-BHRF1-3 can suppress lytic replication by directly inhibiting Zta expression. Moreover, we identify nucleotide variants that impact the function of miR-BHRF1-3, which may contribute to specific EBV pathologies.

Source: Journal of Virology

DOI: 10.1128/jvi.01495-21

Authors: Devin N. Fachko, Yan Chen, Rebecca L. Skalsky

Institution: Vaccine and Gene Therapy Institute

Language: English

Topic: Viral-associated cancers and disorders

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases