Work

Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing

Year: 2021

Type: article

Source: Nature Biotechnology

DOI: 10.1038/s41587-021-01133-w

Authors: Andrew V. Anzalone, Xin D. Gao, Christopher J. Podracky, Andrew T. Nelson, Luke W. Koblan, Aditya Raguram, Jonathan M. Levy, Jaron A. M. Mercer, David R. Liu

Institutions: Broad Institute, Howard Hughes Medical Institute, Harvard University

Language: English

Topic: CRISPR and Genetic Engineering

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Howard Hughes Medical Institute, U.S. Department of Health and Human Services, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases

Awards: G3405342043, G3768699552, Expanding the Scope of Base Editing, G4428771822, G4630203202, Base editing and prime editing for sickle cell disease, Integrating Chemistry and Evolution to Illuminate Biology and Enable Novel Therapeutics, Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human Disease

OpenAlex ID: W4200345742

FWCI: 26.81

Cites: 57

Cited by: 614

Related to: 10