Year: 2021
Type: article
Abstract: Lysosomes were initially recognized as degradation centers that regulate digestion and recycling of cellular waste. More recent studies document that the lysosome is an important signaling hub that regulates cell metabolism. Our knowledge of the role of lysosomes in immunity is mostly derived from innate immune cells, especially lysosomal degradation-specialized cells such as macrophages and dendritic cells. Their function in adaptive immunity is less understood. However, with the recent emphasis on metabolic regulation of T cell differentiation, lysosomes are entering center stage in T cell immunology. In this review, we will focus on the role of lysosomes in adaptive immunity and discuss recent findings on lysosomal regulation of T cell immune responses and lysosomal dysfunction in T cell aging.
Source: Frontiers in Aging
Authors: Jun Jin, Huimin Zhang, Cornelia M. Weyand, Jorg J. Goronzy
Institutions: Mayo Clinic, Stanford University
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,900
Awards: G2305232878, G366100091, Oligoclonal T Cell Expansion and Rheumatoid Arthritis, G5520316217, G6234123045, G6382565763, G6559812740, G9000017482, G9000051380, G9000060880, G9000107322, G9000110302, G9000123093, G9000126294, G9000137488, G9000144690, G9000150726, G9000222606, G9000269492, The NOTCH Signaling Pathway in Large Vessel Vasculitis, Vaccine and Infection Induced Immunity in the Young and Aged
OpenAlex ID: W4200351829