News Beyond Our Pages
Year: 2021
Type: article
Abstract: IL-33 is a potent epithelium-derived alarmin cytokine with a key role in initiation and maintenance of type 2 immune responses and is generally thought to be released following cellular injury and processed extracellularly into mature bioactive forms. Brusilovsky et al (Nat Immunol 2021 Sep 16; https://doi.org/10.1038/s41590-021-01011-2) discovered a novel pathway where caspase 8 ripoptosome, a cell death rheostat, is assembled following exposure to a diverse set of environmental allergens. Ripoptosome activation mediates intracellular IL-33 processing into an active mature form, which is then released to initiate allergic inflammation and type 2 cytokine production through its cognate receptor, ST2.
Authors: Marc E. Rothenberg, Jean Bousquet
Language: English
Topic: IL-33, ST2, and ILC Pathways
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,700
OpenAlex ID: W4200463717