Work

Repurposing ICG enables MR/PA imaging signal amplification and iron depletion for iron-overload disorders

Year: 2021

Type: article

Abstract: SIR changes in animal models. ICG/Leci also promoted a 100% increase in iron depletion in the liver compared with deferoxamine. The high MR sensitivity and superior photoacoustic contrast, combined with enhanced iron depletion, demonstrate that ICG/Leci is a promising theranostic agent for simultaneous detection and treatment of iron-overload disorders.

Source: Science Advances

DOI: 10.1126/sciadv.abl5862

Authors: Huirong Lin, Yu Zhou, Jiaming Wang, Huimeng Wang, Tianhong Yao, Hu Chen, Huili Zheng, Yang Zhang, En Ren, Lai Jiang, Chengchao Chu, Xiaoyuan Chen, Jingsong Mao, Fudi Wang, Gang Liu

Institutions: Xiamen University, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Zhejiang University, National University of Singapore, First Affiliated Hospital of University of South China, University of South China

Language: English

Topic: Nanoplatforms for cancer theranostics

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,500

OpenAlex ID: W4200511809

FWCI: 2.127

Cites: 60

Cited by: 45

Related to: 10