Complete remission in a patient with widely metastatic HER2-amplified pancreatic adenocarcinoma following multimodal therapy informed by tumor sequencing and organoid profiling
Year: 2021
Type: preprint
Study design: Case Report
Abstract: Here, we demonstrate a complete clinical response achieved in a patient with HER2+ metastatic pancreatic ductal adenocarcinoma to a coordinated barrage of anti-HER2, personalized vaccine and checkpoint inhibition immunotherapy, radiation, and chemotherapy. Comprehensive organoid profiling with drug sensitivity screening and drug testing suggested a vulnerability to anti-HER2 directed therapy, facilitating personalized treatment selection for our patient, which contributed to her clinical benefit. Immune response monitoring following personalized vaccine, radiation and checkpoint inhibition showed a sustained increase in neoantigen specific T cell response.
Source: medRxiv
Authors: Daniel A King, Amber R Smith, Gino Pineda, Michitaka Nakano, Flavia Michelini, S. Peter Goedegebuure, Sheeno Thyparambil, Wei-Li Liao, Aaron McCormick, Jihang Ju, Michele Cioffi, Xiuli Zhang, Jasreet Hundal, Malachi Griffith, Carla Grandori, Maddy Pollastro, Rachele Rosati, Astrid Margossian, Payel Chatterjee, Trevor Ainge, Marta Flory, Paolo Ocampo, Lee-may Chen, George A Poultsides, Ari D Baron, Daniel T Chang, Joseph M Herman, William E Gillanders, Haeseong Park, William A Hoos, Mike Nichols, George A Fisher, Calvin J Kuo
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4200526171