Work

Vessels Sing Their ARIAs: The Role of Vascular Amyloid in the Age of Aducanumab

Year: 2021

Type: editorial

Abstract: We review the implications of the recently approved aducanumab amyloid-β immunotherapy for treating Alzheimer disease with comorbid cerebral amyloid angiopathy. In clinical trials, amyloid-β immunotherapy has been associated with a high rate of amyloid-related imaging abnormalities, potentially driven by coexisting cerebral amyloid angiopathy. Therefore, immunotherapy's efficacy in patients may be modified by coexisting cerebrovascular pathology. We discuss the contributions of cerebral amyloid angiopathy on the development of amyloid-related imaging abnormalities and propose strategies to identify cerebral amyloid angiopathy in patients considered for immunotherapy.

Source: Stroke

DOI: 10.1161/strokeaha.121.036873

Authors: Lukas Sveikata, Andreas Charidimou, Anand Viswanathan

Institutions: University of Geneva, Harvard University, Massachusetts General Hospital, University Hospital of Geneva

Language: English

Topic: Intracerebral and Subarachnoid Hemorrhage Research

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute on Aging, National Institute of Neurological Disorders and Stroke