Year: 2021
Type: review
Abstract: Oxygen (O 2 ) toxicity remains a concern, particularly to the lung. This is mainly related to excessive production of reactive oxygen species (ROS). Supplemental O 2 , i.e. inspiratory O 2 concentrations (F I O 2 ) > 0.21 may cause hyperoxaemia (i.e. arterial (a) PO 2 > 100 mmHg) and, subsequently, hyperoxia (increased tissue O 2 concentration), thereby enhancing ROS formation. Here, we review the pathophysiology of O 2 toxicity and the potential harms of supplemental O 2 in various ICU conditions. The current evidence base suggests that PaO 2 > 300 mmHg (40 kPa) should be avoided, but it remains uncertain whether there is an “optimal level” which may vary for given clinical conditions. Since even moderately supra-physiological PaO 2 may be associated with deleterious side effects, it seems advisable at present to titrate O 2 to maintain PaO 2 within the normal range, avoiding both hypoxaemia and excess hyperoxaemia.
Source: Critical Care
Institutions: University College London, The University of Melbourne, Wellington Hospital, Medical Research Institute of New Zealand, Ollscoil na Gaillimhe – University of Galway, University Hospital Galway, Centre Hospitalier Universitaire d'Angers, Université Libre de Bruxelles, Erasmus Hospital, University of Helsinki, Helsinki University Hospital, University of Copenhagen, Frederiksberg Hospital, Universität Ulm, University Hospital Ulm
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,490
OpenAlex ID: W4200543832