Quantitative and qualitative evaluation of 60 Labiatae species, growing in Greece, regarding the content of selected abietane-type diterpenes using 1H-qNMR.
Year: 2021
Type: conference-paper
Abstract: Carnosic acid (CA) and carnosol (CS) are abietane-type diterpenes with plenty of biologic properties [ 1 ] [ 2 ]. Quantitative and qualitative evaluation of 60 plant species of Lamiaceae, growing in Greece, regarding their content in CA, 12-methoxy-carnosic acid (12MΟCA), CS and 7-methoxy-epirosmanol (7MER) using 1 H-qNMR is presented.The methanolic extracts from leaves of species: Ballota, Hyssopus, Lavandula, Marubium, Nepeta, Phlomis, Ocimum, Origanum, Rosmarinus, Salvia, Stachys, Coridothymus, Mentha, Melissa, Sideritis, Satureja, Teucrium , Lamium and Betonica , were analysed using as standards the isolated and fully structurally characterized metabolites by our group. At least one of the target compounds was detected in 29 species: Rosmarinus (2), Salvia (23), Melissa , Ocimum , Mentha (2). 7MER has not been determined in any of the extracts. All three CA, CS and 12OMCA, were identified only in Salvia (9) and Rosmarinus (2). The richest source in CA was S. pomifera subsp. pomifera (Cretan sage) ( 21.6±0.6 mg/g dry leaves)> S. fruticosa (Greek sage) (12.5±1.6 mg/g)> S. officinalis L. (Common sage) ( 11.7±4.3 mg/g), in CS was S. officinalis ( 1.1±0.4 mg/g)> R. officinalis L. (1.1±0.1 mg/g)> S. canariensis ( 1.1±0.3 mg/g) while in 12OMCA was S. microphylla ( 10.7±3.3 mg/g)> S. officinalis (6.1±2.3 mg/g)> S. fruticosa ( 3.1±0.3 mg/g). Salvia and Rosemary revealed as best sources for CA, CS and 12MOCA among the studied species. 1 H-qNMR spectroscopy offers a useful tool for the quantitative and qualitative analysis of the examined compounds in complex extracts, in a simple, rapid and direct way without sample deterioration. Publication History Article published online: 13 December 2021 © 2021. Thieme. All rights reserved. Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart, Germany
Source: Planta Medica
Authors: P Kallimanis, P. Magiatis, Tsiaka Th, P. Zoumpoulakis, A. Panagiotopoulou, I. Chinou
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
Funders: Schlumberger Foundation, Slovenská Akadémia Vied, European Commission, National Natural Science Foundation of China, Austrian Science Fund, Fonds Wetenschappelijk Onderzoek, Bulgarian National Science Fund, Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, Mashhad University of Medical Sciences, Universidade de Lisboa, Walailak University, Vlaamse regering, Priority Academic Program Development of Jiangsu Higher Education Institutions, Hellenic Foundation for Research and Innovation, Innovációs és Technológiai Minisztérium, Thailand Science Research and Innovation, Fundação para a Ciência e a Tecnologia, European Regional Development Fund, Nemzeti Kutatási, Fejlesztési és Innovaciós Alap
OpenAlex ID: W4200563903