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Synthesis of both enantiomers and the 13C derivative of CPI-2850, the major metabolite of Devimistat

Year: 2021

Type: article

Abstract: A practical synthesis of CPI-2850, the major metabolite of Devimistat (CPI-613® (6,8-bis-benzylsulfanyloctanoic acid)), has been developed to synthesize multigram quantities for enantiomeric separation. Using enantioenriched (S)-(−)-1,2,4-butanetriol pure (S)-CPI-2850 enantiomer was synthesized to identify the individual enantiomers after enantiomeric resolution. A slightly modified synthetic route was used to synthesize 13C-CPI-2850 useful for metabolic studies.

Source: Results in Chemistry

DOI: 10.1016/j.rechem.2021.100268

Authors: Poli Adi Narayana Reddy, Zachary Stine, Joseph M. Salvino

Institution: The Wistar Institute

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,000

OpenAlex ID: W4200598710

FWCI:

Cites: 7

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Related to: 10