Year: 2021
Type: review
Abstract: Non-alcoholic fatty liver disease (NAFLD) is a continuous progression of pathophysiologic stages that is challenging to diagnose due to its inherent heterogeneity and poor standardization across a wide variety of diagnostic measures. NAFLD is heritable, and several loci have been robustly associated with various stages of disease. In the past few years, larger genetic association studies using new methodology have identified novel genes associated with NAFLD, some of which have shown therapeutic promise. This mini-review provides an overview of the heterogeneity in NAFLD phenotypes and diagnostic methods, discusses genetic associations in relation to the specific stages for which they were identified, and offers a perspective on the design of future genetic mapping studies to accelerate therapeutic target identification.
Source: Frontiers in Endocrinology
Authors: Xiaomi Du, Natalie DeForest, Amit R. Majithia
Institution: University of California San Diego
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,950
Awards: G1275747955, G1462415530, G1547284777, Combining experiments of man and nature to target human insulin resistance, G2387613229, Prospective Functional Characterization of All Possible Missense Variants in HNF1A, G598865872, G6331392353, Training Program in Basic and Clinical Genetics, Diabetes Research Center (DRC)
OpenAlex ID: W4200623414