Year: 2009
Type: book-review
Abstract: D-Penicillamine is widely used in the treatment of rheumatoid arthritis (RA).the pharmacological properties and the therapeutic use of the drug are thoroughly discussed in this comprehensive vol ume.No doubt, D-penicillamine has powerful effects on different immunological functions and parameters, such as autoantibodies, rheumatoid factors, and immune complexes.Its use is hampered by serious side-effects, such as nephropathy and myasthenia gravislikew syndrome.It is not clear if the therapeutic value of the drug outweighs the risk of serious side-effects.A thorough controlled multicentre trial comparing D-penicillamine 125 and 500 mg per day with placebo under 36 weeks in patients with active RA (J.E. Ward)gave 'minimal changes' regarding improvement in the num ber of tender joints, grip strength and other clinical signs in patients
DOI: 10.1159/000233169
Authors: D.E. Griswold, S. Alessi, D.T. Walz, Kozo Yokomuro, Ayako Mabuchi, Mitsuyoshi Saizawa, Naoshi Kojima, Alan S. Rosenthal, Yoshitami Kimura, F.B. de Brito, T.H.P. Hanahoe, P. Shah, G.B. West, A.W. Wheeler, D.M. Moran, B.E. Robins, A. Driscoll, D.M. Moran, R. Standring, D.C. Henderson, Kiyoshi Furuichi, Hisanori Ezoe, Toshiyuki Takemoto, Tadashi Obara, Rafi Ahmad, Christoph C. Zielinski, Josef W. Mannhalter, Gerhard Zlabinger, Alfred Rockenschaub, Martha M. Eibl, Sylvi Aanderud, Roald Matre, Jan Erik Varhaug, Marc Langweiler, Gary L. Cockerell, A. Khandwala, S. Coutts, I. Weinryb, Haruhisa Mita, Yasuo Yui, Muneo Suzuki, Hiroshi Yasueda, Takao Shida, Bengt BjÖrkstén, Gunnar Hattevig, Bengt Kjellman, Staffan Ahlstedt, Wolfgang Richter, Murray W. Hostetter, Christopher A. Dawson, Vernon L. Moore, Clara K. Ju-Ger, Etsuko Masuda, Carlo Garzelli, Mario Campa, Antonella Forlani, Vittorio Colizzi, Giuseppe Falcone, Raymond G. Slavin, Patricia S. Hutcheson, Shirley D. Rohrer
Language: English
Open Access status: bronze
OpenAlex ID: W4205113192