Year: 2022
Type: review
Abstract: T cell activation, proliferation, and differentiation into effector and memory states involve massive remodeling of T cell size and molecular content and create a massive increase in demand for energy and amino acids. Protein synthesis is an energy- and resource-demanding process; as such, changes in T cell energy production are intrinsically linked to proteome remodeling. In this review, we discuss how protein synthesis and degradation change over the course of a T cell immune response and the crosstalk between these processes and T cell energy metabolism. We highlight how the use of high-resolution mass spectrometry to analyze T cell proteomes can improve our understanding of how these processes are regulated.
Authors: Julia M. Marchingo, Doreen A. Cantrell
Institution: University of Dundee
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,790
Awards: Signalling pathways that control T cell metabolism and T cell fate, Signalling pathways that control T cell metabolism and T cell fate, Serine kinase pathways that determine T lymphocyte activation and cell fate choices., Unravelling how protein signalling networks integrate to control T cell fate
OpenAlex ID: W4205154917