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Pharmahuasca and DMT Rescue ROS Production and Differentially Expressed Genes Observed after Predator and Psychosocial Stress: Relevance to Human PTSD

Year: 2022
Type: article
Abstract: R compared to 5-HT. DMT and pharmahuasca reduced ROS production in the PFC and HC, while harmaline had mixed effects. Treatments normalized 9, 12, and 14 overlapping DEGs, and pathway analysis implicated that genes were involved in ROS production, inflammation, growth factor signaling, neurotransmission, and neuroplasticity.
DOI: 10.1021/acschemneuro.1c00660
Authors: D. Parker Kelley, Katy Venable, Aspasia Destouni, Gerald Billac, Philip Ebenezer, Krisztian Stadler, Charles Nichols, Steven Barker, Joseph Francis
Language: English
Field: Psychology
Open Access status: hybrid
Estimated APC paid: $5,000
OpenAlex ID: W4205158881
FWCI: 7.529
Cites: 114
Cited by: 42
Related to: 10