Faculty Opinions recommendation of Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization.
Year: 2019
Type: peer-review
Abstract: Metastatic seeding by disseminated cancer cells principally occurs in perivascular niches.Here, we show that mechanotransduction signaling triggered by the pericyte-like spreading of disseminated cancer cells on host tissue capillaries is critical for metastatic colonization.Disseminated cancer cells employ cell adhesion molecule L1 (L1CAM) to spread on capillaries and activate the mechanotransduction effectors Yes-associated protein (YAP) and myocardinrelated transcription factor (MRTF).This L1CAM-mediated spreading is robust enough to displace resident pericytes, which also use L1CAM for perivascular spreading.L1CAM activates YAP by engaging β1 integrin and integrin linked kinase (ILK).L1CAM-YAP signaling enables
Author: Andrew Dudley
Institution: University of Virginia
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4205234441