Response to Makiyama, Momosaki, Yodoshi, et al
Year: 2022
Type: article
Abstract: We thank Makiyama and colleagues for their careful review and critique of our manuscript, Progression of Frailty in Survivors of Childhood Cancer: a St. Jude Lifetime Cohort Report, and for the suggestion that we construct an additional model to assure that frailty is in fact a cause of mortality in childhood cancer survivors (1). Given that we only had 77 deaths in the cohort, 22 related to a second malignant neoplasm and 20 to cardiac causes, our power to evaluate multiple risk factors for specific causes of death was limited. Our aim was to determine if frailty at one time point was associated with mortality over a 5- to 6-year time period, even after accounting for chronic disease. We continue to follow this cohort and will consider additional modeling of mortality outcomes in the future. None. Role of the funder: Not applicable. Disclosures: The authors have no disclosures. Author contributions: Writing, original draft—all authors; writing, editing and revision—all authors. No new data were generated or used for this response.
DOI: 10.1093/jnci/djac002
Authors: Angela Delaney, Kirsten K Ness
Institution: St. Jude Children's Research Hospital
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4205337087