Work

Cocaine increases stimulation-evoked serotonin efflux in the nucleus accumbens

Year: 2022

Type: article

Abstract: Serotonin plays a vital role in drug addiction. Here, using N-shaped fast-scan cyclic voltammetry, we demonstrated the effect of cocaine on the phasic release of serotonin at the nucleus accumbens core. To the best of our knowledge, this has not previously been elucidated. Our results not only reinforce the role of serotonin in the mechanism of action of cocaine but also help to fill a gap in our knowledge and provide a baseline for future studies in cocaine addiction.

Source: Journal of Neurophysiology

DOI: 10.1152/jn.00420.2021

Authors: Jason Yuen, Abhinav Goyal, Aaron E. Rusheen, Abbas Z. Kouzani, Michael Berk, Jee Hyun Kim, Susannah J. Tye, Charles D. Blaha, Kevin E. Bennet, Kendall H. Lee, Yoonbae Oh, Hojin Shin

Institutions: Barwon Health, Mayo Clinic, Deakin University, The University of Queensland

Language: English

Topic: Neurotransmitter Receptor Influence on Behavior

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Department of Health and Aged Care, Australian Government, National Health and Medical Research Council, National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke

Awards: G1395296310, G1666418011, G3011382085, G3116570297, Novel therapies for psychiatric disorders, Development of advanced voltammetric method for basal neurotransmitter level measurement, Medical Scientist Training Program at Mayo Clinic

OpenAlex ID: W4205343096

FWCI: 1.869

Cites: 48

Cited by: 22

Related to: 10