Year: 2022
Type: review
Abstract: Humans produce and remove 1011 platelets daily to maintain a steady-state platelet count. The tight regulation of platelet production and removal from the blood circulation prevents anomalies in both processes from resulting in reduced or increased platelet count, often associated with the risk of bleeding or overt thrombus formation, respectively. This review focuses on the role of glycans, also known as carbohydrates or oligosaccharides, including N- and O-glycans, proteoglycans, and glycosaminoglycans, in human and mouse platelet and megakaryocyte physiology. Based on recent clinical observations and mouse models, we focused on the pathologic aspects of glycan biosynthesis and degradation and their effects on platelet numbers and megakaryocyte function.
Source: Blood
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G1754476332, G3369133349, Endocytosis in platelet and megakaryocyte biology, G7988749740, Glycans in Blood Homeostasis and Disease, G8588361313, Biosynthesis and Function of Lactosaminyl Glycans in Hematopoiesis, G9000250752, Molecular and Clinical Glycobiology of the Bone Marrow Environment, Carbohydrate-Mediated Platelet Clearance
OpenAlex ID: W4205493746