Work

Novel VHH-Based Tracers with Variable Plasma Half-Lives for Imaging of CAIX-Expressing Hypoxic Tumor Cells

Year: 2022

Type: article

Abstract: In]In-DTPA-B9 has a high affinity to CAIX and shows specific targeting to CAIX in head and neck cancer xenografts. The addition of ABD prolonged plasma half-life, increased tumor uptake, and enabled SPECT/CT imaging. This uptake was, however, partly CAIX- independent, precluding the ABD-tracers for use in hypoxia quantification in this tumor type.

Source: Molecular Pharmaceutics

DOI: 10.1021/acs.molpharmaceut.1c00841

Authors: Sanne A.M. van Lith, Fokko J. Huizing, Gerben M. Franssen, Bianca A.W. Hoeben, Jasper Lok, Sofia Doulkeridou, Otto C. Boerman, Martin Gotthardt, Paul M.P. van Bergen en Henegouwen, Johan Bussink, Sandra Heskamp

Institutions: Radboud University Medical Center, University Medical Center Utrecht, Utrecht University

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,000

Funders: Radboud Universiteit, Radboud Universitair Medisch Centrum

OpenAlex ID: W4205583659

FWCI: 1.705

Cites: 38

Cited by: 15

Related to: 10