Association of Dietary Patterns with MRI Markers of Hepatic Inflammation and Fibrosis in the MAST4HEALTH Study
Year: 2022
Type: article
Abstract: Whereas the etiology of non-alcoholic fatty liver disease (NAFLD) is complex, the role of nutrition as a causing and preventive factor is not fully explored. The aim of this study is to associate dietary patterns with magnetic resonance imaging (MRI) parameters in a European population (Greece, Italy, and Serbia) affected by NAFLD. For the first time, iron-corrected T1 (cT1), proton density fat fraction (PDFF), and the liver inflammation fibrosis score (LIF) were examined in relation to diet. A total of 97 obese patients with NAFLD from the MAST4HEALTH study were included in the analysis. A validated semi-quantitative food frequency questionnaire (FFQ) was used to assess the quality of diet and food combinations. Other variables investigated include anthropometric measurements, total type 2 diabetes risk, physical activity level (PAL), and smoking status. Principal component analysis (PCA) was performed to identify dietary patterns. Six dietary patterns were identified, namely “High-Sugar”, “Prudent”, “Western”, “High-Fat and Salt”, “Plant-Based”, and “Low-Fat Dairy and Poultry”. The “Western” pattern was positively associated with cT1 in the unadjusted model (beta: 0.020, p-value: 0.025) and even after adjusting for age, sex, body mass index (BMI), PAL, smoking, the center of the study, and the other five dietary patterns (beta: 0.024, p-value: 0.020). On the contrary, compared with low-intake patients, those with medium intake of the “Low-Fat Dairy and Poultry” pattern were associated with lower values of cT1, PDFF, and LIF. However, patients with a “Low-Fat Dairy and Poultry” dietary pattern were negatively associated with MRI parameters (cT1: beta: −0.052, p-value: 0.046, PDFF: beta: −0.448, p-value: 0.030, LIF: beta: −0.408, p-value: 0.025). Our findings indicate several associations between MRI parameters and dietary patterns in NAFLD patients, highlighting the importance of diet in NAFLD.
Authors: Athina I. Amanatidou, Andriana C. Kaliora, Charalampia Amerikanou, Stefan Stojanoski, Natasa Milosevic, Chara Vezou, Mirjana Beribaka, Rajarshi Banerjee, Ioanna-Panagiota Kalafati, Ilias Smyrnioudis, Mary Jo Kurth, Aimo Kannt, M. Pilar Francino, Sophie Visvikis-Siest, Panos Deloukas, Carlos Llorens, Fernando Marascio, Natasa Milic, Milica Medic-Stojanoska, Amalia Gastaldelli, Maria Giovanna Trivella, George V. Dedoussis
Institutions: Harokopio University of Athens, University of Novi Sad, Oncology Institute of Vojvodina, University of East Sarajevo, Perspectum Ltd. (United Kingdom), Chios Mastiha Growers Association, Randox (United Kingdom), Fraunhofer Institute for Translational Medicine and Pharmacology, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Inserm, Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire, Université de Lorraine, Queen Mary University of London, William Harvey Research Institute, Universitat de València, Parc Científic de la Universitat de València, INGV Osservatorio Etneo, Klinički centar Vojvodine, Istituto di Fisiologia Clinica, National Research Council, Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,618
OpenAlex ID: W4205777256