Interorgan crosstalk in pancreatic islet function and pathology
Year: 2022
Type: review
Abstract: Pancreatic β cells secrete insulin in response to glucose, a process that is regulated at multiple levels, including a network of input signals from other organ systems. Impaired islet function contributes to the pathogenesis of type 2 diabetes mellitus (T2DM), and targeting inter-organ communications, such as GLP-1 signalling, to enhance β-cell function has been proven to be a successful therapeutic strategy in the last decade. In this review, we will discuss recent advances in inter-organ communication from the metabolic, immune and neural system to pancreatic islets, their biological implication in normal pancreas endocrine function and their role in the (mal)adaptive responses of islet to nutrition-induced stress.
Source: FEBS Letters
Authors: Ronald M. Evans, Zong Wei
Institutions: Salk Institute for Biological Studies, Mayo Clinic in Arizona
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Ellison Medical Foundation, California Institute for Regenerative Medicine, Glenn Foundation for Medical Research, Leona M. and Harry B. Helmsley Charitable Trust, NOMIS Stiftung, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences
Awards: G2147928738, Engineering human islet-like organoids for transplantation, G2506757200, DETECTION AND MODELS OF TOXICANT EXPOSURE, G352863456, Hormonal Regulation of Mammalian Gene Expression, Spatial Regulation of Developmental Gene Expression, G6046929299, G637574655, G7026577839, A role of chromatin remodeling complexes in beta cell dysfunction, Role of Immune Mechanisms in Athersclerosis and Inflammation, G7986952895, Cancer Center Support Grant (CCSG)
OpenAlex ID: W4205803079