The association of lung function and pulmonary vasculature volume with cardiorespiratory fitness in the community
Year: 2022
Type: article
Study design: Observational Study
Abstract: Background Cardiorespiratory fitness is not limited by pulmonary mechanical reasons in the majority of adults. However, the degree to which lung function contributes to exercise response patterns among ostensibly healthy individuals remains unclear. Methods We examined 2314 Framingham Heart Study participants who underwent cardiopulmonary exercise testing (CPET) and pulmonary function testing. We investigated the association of forced expiratory volume in 1 s (FEV 1 ), forced vital capacity (FVC), FEV 1 /FVC and diffusing capacity of the lung for carbon monoxide ( D LCO ) with the primary outcome of peak oxygen uptake ( V ′ O 2 ) along with other CPET parameters using multivariable linear regression. Finally, we investigated the association of total and peripheral pulmonary blood vessel volume with peak V ′ O 2 . Results We found lower FEV 1 , FVC and D LCO were associated with lower peak V ′ O 2 . For example, a 1 L lower FEV 1 and FVC was associated with a 7.1% (95% CI 5.1–9.1%) and 6.0% (95% CI 4.3–7.7%) lower peak V ′ O 2 , respectively. By contrast, FEV 1 /FVC was not associated with peak V ′ O 2 . Lower lung function was associated with lower oxygen uptake efficiency slope, oxygen pulse slope, V ′ O 2 at anaerobic threshold (AT), minute ventilation ( V ′ E ) at AT and breathing reserve. In addition, lower total and peripheral pulmonary blood vessel volume were associated with lower peak V ′ O 2 . Conclusions In a large, community-based cohort of adults, we found lower FEV 1 , FVC and D LCO were associated with lower exercise capacity, as well as oxygen uptake efficiency slope and ventilatory efficiency. In addition, lower total and peripheral pulmonary blood vessel volume were associated with lower peak V ′ O 2 . These findings underscore the importance of lung function and blood vessel volume as contributors to overall exercise capacity.
Source: European Respiratory Journal
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G1270688439, Metabolic Signatures of Impaired Cardiorespiratory Fitness: Correlates, Prognostic Significance and Modulation with Exercise Training, G2577284571, G2581677850, G278200998, Characterization of Molecular and Physiologic Signatures of Impaired Multi-Organ System Reserve Capacity During Exercise in Heart Failure with Preserved Ejection Fraction, G3129668750, Characterization of Functional Iron Deficiency and Repletion in Heart Failure with Preserved Ejection Fraction, G3405256882, G355172997, Eicosanoid Profiles as Determinants of HFpEF, G426421887, G483743613, G4928577803, G4976486911, G5164707915, The Framingham Heart Study, Computed Tomographic Insights Into Pulmonary Hypertension, G6694649659, G6801099290, G7003485072, G7080758651, Metabolic Profiling of Exercise to Predict Cardiometabolic Risk, Mentoring in Patient-Oriented and Translational HFpEF Research, Proteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF Spectrum, G926069642
OpenAlex ID: W4205877338