Year: 2022
Type: article
Abstract: Cardiovascular diseases (CVDs) are the leading cause of death globally, representing approximately 32% of all deaths worldwide. Molecular chaperones are involved in heart protection against stresses and age-mediated accumulation of toxic misfolded proteins by regulation of the protein synthesis/degradation balance and refolding of misfolded proteins, thus supporting the high metabolic demand of the heart cells. Heat shock protein 90 (HSP90) is one of the main cardioprotective chaperones, represented by cytosolic HSP90a and HSP90b, mitochondrial TRAP1 and ER-localised Grp94 isoforms. Currently, the main way to study the functional role of HSPs is the application of HSP inhibitors, which could have a different way of action. In this review, we discussed the recently investigated role of HSP90 proteins in cardioprotection, atherosclerosis, CVDs development and the involvements of HSP90 clients in the activation of different molecular pathways and signalling mechanisms, related to heart ageing.
DOI: 10.3390/ijms23020649
Institutions: Vitebsk State Academy of Veterinary Medicine, Institute of Experimental Cardiology, Research Institute of Human Morphology, National Medical Research Center of Cardiology, Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences, Institute for Atherosclerosis Research
Language: English
Topic: Heat shock proteins research
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,408
Funder: Russian Science Foundation
Award: G7977959776
OpenAlex ID: W4205911047