Work

Relative contribution of low-density and asymptomatic infections to Plasmodium vivax transmission in the Amazon: pooled analysis of individual participant data from population-based cross-sectional surveys

Year: 2022

Type: article

Abstract: Background: infections remain largely undetected and untreated and may contribute significantly to malaria transmission in the Amazon. Methods: infections and examined how parasite density relates to clinical manifestations and mosquito infection in Amazonian settings. Findings: transmission, while asymptomatic carriers are the source of 28·2% to 79·2% of mosquito infections. Interpretation: carriers constitute a vast infectious reservoir that, if targeted by malaria elimination strategies, could substantially reduce malaria transmission in the Amazon. Infected children may remain asymptomatic despite high parasite densities that elicit clinical manifestations in adults. Funding: US National Institutes of Health, Fundação de Amparo à Pesquisa do Estado de São Paulo, and Belgium Development Cooperation.

Source: The Lancet Regional Health - Americas

DOI: 10.1016/j.lana.2021.100169

Authors: Marcelo U. Ferreira, Rodrigo M. Corder, Igor C. Johansen, Johanna H. Kattenberg, Marta Moreno, Angel Rosas-Aguirre, Simone Ladeia-Andrade, Jan E. Conn, Alejandro Llanos-Cuentas, Dionicia Gamboa, Anna Rosanas-Urgell, Joseph M. Vinetz

Institutions: University of Lisbon, Universidade de São Paulo, Universidade Nova de Lisboa, Instituut voor Tropische Geneeskunde, London School of Hygiene & Tropical Medicine, UCLouvain, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, New York State Department of Health, State University of New York, Wadsworth Center, University at Albany, State University of New York, Universidad Peruana Cayetano Heredia, Instituto de Medicina Tropical Alexander von Humboldt, Yale University

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,000

Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo, Universidade de São Paulo, National Institutes of Health, National Institute of Allergy and Infectious Diseases

Awards: Prospects for residual malaria elimination in rural Brazilian Amazon: targeting Plasmodium vivax reservoir hosts, G295657101, Amazonian Center of Excellence in Malaria Research, Scientific bases for residual malaria elimination in the Brazilian Amazon, The clinically silent Plasmodium vivax reservoir in the Amazon: a systematic review and pooled analysis of individual-level data from population-based surveys

OpenAlex ID: W4205925671

FWCI: 7.947

Cites: 29

Cited by: 36

Related to: 10