Work

The genetics of glaucoma: Disease associations, personalised risk assessment and therapeutic opportunities‐A review

Year: 2022

Type: review

Abstract: Glaucoma refers to a heterogenous group of disorders characterised by progressive loss of retinal ganglion cells and associated visual field loss. Both early-onset and adult-onset forms of the disease have a strong genetic component. Here, we summarise the known genetic associations for various forms of glaucoma and the possible functional roles for these genes in disease pathogenesis. We also discuss efforts to translate genetic knowledge into clinical practice, including gene-based tests for disease diagnosis and risk-stratification as well as gene-based therapies.

Source: Clinical and Experimental Ophthalmology

DOI: 10.1111/ceo.14035

Authors: Inas F. Aboobakar, Janey L. Wiggs

Institutions: Massachusetts Eye and Ear Infirmary, Harvard University

Language: English

Topic: Glaucoma and retinal disorders

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Eye Institute