Get started
Work

Metabolic reprogramming in a slowly developing orthologous model of polycystic kidney disease

Year: 2022
Type: article
Abstract: This report delineates the evolution of metabolic changes occurring during autosomal dominant polycystic kidney disease (ADPKD) progression. Using an orthologous model, we performed kidney metabolomics and confirmed dysregulation of metabolic pathways previously found altered in nonorthologous or rapidly-progressive PKD models. Importantly, we identified novel alterations, including augmentation of kynurenines, polyamines, and indoles, suggesting increased inflammation and microbial dysbiosis that provide insights into PKD pathomechanisms and may prove helpful for diagnosing, monitoring, and treating ADPKD.
DOI: 10.1152/ajprenal.00262.2021
Authors: Katharina Hopp, Emily K. Kleczko, Berenice Y. Gitomer, Michel Chonchol, Jost Klawitter, Uwe Christians, Jelena Klawitter
Language: English
Subfield: Genetics
Open Access status: green
Awards: The role of inflammation in the progression of polycystic kidney disease, Defining the functional role of T-cells in Autosomal Dominant Polycystic Kidney Disease pathology, G5507274739, G6156312026, G6504526518, G7298477120, G7925021721
OpenAlex ID: W4206107451
FWCI: 4.088
Cites: 59
Cited by: 36
Related to: 10