Year: 2021
Type: review
Abstract: Cancer, especially the solid tumor sub-set, poses considerable challenges to modern medicine owing to the unique physiological characteristics and substantial variations in each tumor's microenvironmental niche fingerprints. Though there are many treatment methods available to treat solid tumors, still a considerable loss of life happens, due to the limitation of treatment options and the outcomes of ineffective treatments. Cancer cells evolve with chemo- or radiation-treatment strategies and later show adaptive behavior, leading to failed treatment. These challenges demand tailored and individually apt personalized treatment methods. Bacteriophages (or phages) and phage-based theragnostic vectors are gaining attention in the field of modern cancer medicine, beyond their bactericidal ability. With the invention of the latest techniques to fine-tune phages, such as in the field of genetic engineering, synthetic assembly methods, phage display, and chemical modifications, noteworthy progress in phage vector research for safe cancer application has been realized, including use in pre-clinical studies. Herein, we discuss the distinct fingerprints of solid tumor physiology and the potential for bacteriophage vectors to exploit specific tumor features for improvised tumor theragnostic applications.
DOI: 10.3390/ijms23010402
Institution: Jichi Medical University
Language: English
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,160
Awards: G1255948260, G2307863436, Development of bacterial flora editing technology for overcoming diseases caused by bacterial flora disorder, Development of a new method for prevention of colorectal cancer by eliminating colibactin-producing bacteria, G3012914509, Development of a novel agent which selectively kills drug-resistant Staphylococcus aureus, mecAを標的としたMRSAに対する抗菌ファージの開発, Development of antimicrobials targeting a wide range of bacteria., G7862657934
OpenAlex ID: W4206161296