Intracranial lesion patterns on brain computed tomography and their association with full recovery in adolescents and young people with mild traumatic brain injury
Year: 2021
Type: article
Abstract: Background: Cinnamaldehyde (CA) is known for its antioxidant, antiinflammatory, antiapoptotic and neuroprotective effects.The aim of this study was to investigate possible antioxidant, antiinflammatory, antiapoptotic and neuroprotective effects of CA in a rat mild TBI model.Methods: Wistar albino male rats were randomly divided into groups: control (n ¼ 9), TBI (n ¼ 9), vehicle (0.1% Tween 80, 0.1 ml/100 gr, n ¼ 8), and CA (100 mg/kg) (n ¼ 9).Under anesthesia, TBI was induced by weight-drop model.Twenty-four hours after TBI, the rats were decapitated.In brain tissue, activities of myeloperoxidase, luminol-and lucigenin were measured.Brain injury was graded histopathologically following hematoxylin-eosin staining.Before and 24-hour after TBI; modified Bederson test for motor neurological examination; Y-maze and novel object recognition test for evaluation of hippocampal functions were performed.Results: Higher levels myeloperoxidase activity (p < 0.001) in the TBI group were found to be suppressed in the CA group (p < 0.05).Luminol and lucigenin activity, which was found to be increased in the brain tissues of the TBI group (p < 0.0001; for both groups) was decreased in the group that had received CA treatment (p < 0.001; for both comparisons).In the CA group histological damage score in the cerebral cortex and dentate gyrus was lower (p < 0.001; for both comparisons), when compared to the TBI group (p < 0.001; for both comparisons).In the TBI group, number of entries and spontaneous alternation percentage in Y-maze test was decreased (p < 0.05 and p < 0.01; respectively).Conclusion: CA treatment after TBI has shown neuroprotective effects via antioxidant and antiinflammatory properties.Histological damage score was reversed with CA treatment.Also, CA treatment improved TBI related acute hippocampal dysfunction.These findings suggest that CA should be further evaluated for its possible therapeutic effect in TBI.
Source: Brain and Spine
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,033
OpenAlex ID: W4206177967