The effect of age on CD4+ T-cell recovery in HIV-suppressed adult participants: a sub-study from AIDS Clinical Trial Group (ACTG) A5321 and the Bone Loss and Immune Reconstitution (BLIR) study
Year: 2022
Type: article
Abstract: Older age could be a risk factor for suboptimal CD4+ T-cell recovery in HIV-infected patients despite successful viral suppression. However, evaluation of this effect could be confounded by age-related immune processes such as decreased thymus output, increased immune activation and exhaustion. Here, we established a semi-mechanistic population model simultaneously describing naïve and memory CD4+ T-cell trajectories in 122 participants. Covariate analysis accounting for immune activation showed that older age was significantly associated with faster apparent elimination rate of the naïve T-cells. In addition, female sex predicted slower apparent elimination rate of memory T-cells. Simulations showed that the median maximal CD4+ T-cell count on ART treatment was 593 cells/μL (IQR 442-794) in patients aged 50 years or above and 738 cells/μL (IQR 548-1002) in patients aged 18-35 years. The differences in the percentage of subjects achieving sufficient immune reconstitution (CD4+ T-cell count> 500 cells/μL) between the two age groups were 15, 21 and 26% at year 1, 4 years and steady state, respectively, suggesting that advanced age may have a greater impact on long-term CD4+ T-cell recovery.
Source: Immunity & Ageing
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,790
Funders: U.S. Department of Veterans Affairs, Office of Research and Development, Biomedical Laboratory Research and Development, VA Office of Research and Development, National Institutes of Health, Center for AIDS Research, University of Washington, University of North Carolina at Chapel Hill, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Awards: G1185573166, G1571878575, G1779015823, IL-4, a key regulator of bone turnover in HIV and ART, G3533447256, G3741835509, Effect of HIV Infection and HAART on Bone Homeostasis, Bone Loss and Immune Reconstitution in HIV/AIDS, Reversing HIV-induced B cell dysfunction with bisphosphonates, Characterization and modulation of mucosal immunity for HIV prevention in women, G8753787775, G9000240271, Emory Specialized Center of Research Excellence (SCORE) on Sex Differences, The University of North Carolina Center for AIDS Research, G998967326
OpenAlex ID: W4206241463