Work

Faculty Opinions recommendation of Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole.

Year: 2006

Type: peer-review

Abstract: It has been more than 25 years since it was first reported that nifurtimox and benznidazole promote superoxide production in trypanosomes.However, there has been no direct evidence of an association between the drug-induced free radicals and trypanocidal activity.Here, we identify a superoxide dismutase required to protect Trypanosoma brucei from drug-generated superoxide.

Source: Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

DOI: 10.3410/f.1052977.504930

Author: Roberto Docampo

Institution: University of Georgia

Language: English

Topic: Trypanosoma species research and implications

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4206348805

Cites: 20

Cited by:

Related to: 10