Faculty Opinions recommendation of A synthetic synaptic organizer protein restores glutamatergic neuronal circuits.
Year: 2020
Type: peer-review
Abstract: Neuronal synapses undergo structural and functional changes throughout life, which are essential for nervous system physiology.However, these changes may also perturb the excitatory/inhibitory neurotransmission balance and trigger neuropsychiatric and neurological disorders.Molecular tools to restore this balance are highly desirable.Here, we designed and characterized CPTX, a
Authors: Angus Nairn, Shannon Leslie
Institutions: Connecticut Mental Health Center, Yale University
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Funders: Takeda Science Foundation, Japan Agency for Medical Research and Development, Diamond Light Source, European Commission, Keio University, Bundesministerium für Bildung und Forschung, Astellas Pharma, Daiichi Sankyo Foundation of Life Science, Université de Bordeaux, Astellas Foundation for Research on Metabolic Disorders, Medical Research Council, Japan Society for the Promotion of Science, Core Research for Evolutional Science and Technology, Exploratory Research for Advanced Technology, Daiichi Sankyo Europe, H2020 European Research Council
Awards: G1075538165, G1893551499, G2325242462, Extracellular brain proteolysis in neuronal plasticity and neuropsychiatric disorders, G2576085165, Advanced Bioimaging Support, Elusiodation of novel spatiotemporal mechanisms of synapse elimination by groups of complement proteins, G4345692949, Molecular Structure and Engineering of Synaptic Organizer Proteins in Health and Disease, G5968199003, Molecular architecture of a prototypical trans-synaptic complex: GluD2-Cerebellin1-Neurexin1β, G6581542049, G6718509927, G6975707094, Regulation of synapse formation, maintenance, elimination and plasticity by C1q family proteins, G7143159706, G7618363615, Engineering neuronal circuits by artificial synapse organizers, 補体Ｃ１ｑによるシナプス除去機能の新規制御メカニズムの解明, Possibility of treatments for amelioration of spinal cord injury -Regulation of extracellular environments and inflammation control, Verbundprojekt: Anregung des Hippocampus bei älteren Menschen - Teilprojekte 1, 3, 4 und 5, G8277615189, 補体C1qによるシナプス除去機能の新規制御メカニズムの解明, G8501987154, G8538723892
OpenAlex ID: W4206378695