Faculty Opinions recommendation of The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome.
Year: 2008
Type: peer-review
Abstract: Following birth, the breast-fed infant gastrointestinal tract is rapidly colonized by a microbial consortium often dominated by bifidobacteria.Accordingly, the complete genome sequence of Bifidobacterium longum subsp.infantis ATCC15697 reflects a competitive nutrientutilization strategy targeting milk-borne molecules which lack a nutritive value to the neonate.Several chromosomal loci reflect potential adaptation to the infant host including a 43 kbp cluster encoding catabolic genes, extracellular solute binding proteins and permeases predicted to be active on milk oligosaccharides.An examination of in vivo metabolism has detected the hallmarks of milk oligosaccharide utilization via the central fermentative pathway using metabolomic and proteomic approaches.Finally, conservation of gene clusters in multiple isolates corroborates the genomic mechanism underlying milk utilization for this infant-associated phylotype.carbohydrate metabolism ͉ co-evolution ͉ genomics ͉ human milk oligosaccharides
Authors: Steven Salzberg, Adam Phillippy
Institution: Johns Hopkins University
Language: English
Topic: Infant Nutrition and Health
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4206453525