5-Fluorouracil Neurotoxicity in the Absence of Dihydropyrimidine Dehydrogenase Deficiency Case Report
Year: 2022
Type: article
Study design: Case Report
Abstract: 5 fluorouracil (5-FU)-related neurotoxicity is a rare and severe complication of 5-FU administration. Dihydropyrimidine dehydrogenase (DPD) deficiency is associated with an increased risk of serious adverse reactions due to its role in 5-FU metabolism. We report a case of acute reversible neurotoxicity with global areas of diffusion restriction in a patient with colorectal adenocarcinoma being treated with leucovorin calcium, 5-fluorouracil, and oxaliplatin (FOLFOX) without DPD deficiency following uridine triacetate administration.
Source: The Neurohospitalist
Authors: Rebecca Jules, Arushi Thaper, Ryan Foster, Pouya Ameli, Christopher Robinson, Michael Pizzi, Marc-Alain Babi, Carolina B. Maciel, Katharina M. Busl, Raju Reddy, William Roth
Institutions: University of Florida Health, University of Florida
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4206481695