Association Between Change in Accelerometer-Measured and Self-Reported Physical Activity and Cardiovascular Disease in the Look AHEAD Trial
Year: 2022
Type: article
Abstract: OBJECTIVE: To conduct post hoc secondary analysis examining the association between change in physical activity. Measured with self-report and accelerometry, from baseline to 1 and 4 years and cardiovascular disease (CVD) outcomes in the Look AHEAD Trial. RESEARCH DESIGN AND METHODS: Participants were adults with overweight/obesity and type 2 diabetes with physical activity. Data at baseline and year 1 or 4 (n = 1,978). Participants were randomized to diabetes support and education or intensive lifestyle intervention. Measures included accelerometry-measured moderate-to-vigorous physical activity (MVPA), self-reported physical activity, and composite (morbidity and mortality) CVD outcomes. RESULTS: In pooled analyses of all participants, using Cox proportional hazards models, each 100 MET-min/week increase in accelerometry-measured MVPA from baseline to 4 years was associated with decreased risk of the subsequent primary composite outcome of CVD. Results were consistent for changes in total MVPA (hazard ratio 0.97 [95% CI 0.95, 0.99]) and MVPA accumulated in ≥10-min bouts (hazard ratio 0.95 [95% CI 0.91, 0.98]), with a similar pattern for secondary CVD outcomes. Change in accelerometry-measured MVPA at 1 year and self-reported change in physical activity at 1 and 4 years were not associated with CVD outcomes. CONCLUSIONS: Increased accelerometry-measured MVPA from baseline to year 4 is associated with decreased risk of CVD outcomes. This suggests the need for long-term engagement in MVPA to reduce the risk of CVD in adults with overweight/obesity and type 2 diabetes.
Source: Diabetes Care
DOI: 10.2337/dc21-1206
Author: Look AHEAD Study Group
Language: English
Topic: Physical Activity and Health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: General Clinical Research Center, Action for Health in Diabetes Continuation (Look AHEAD-E), 05/16 Action for Health in Diabetes Extension Study - Research Project, 10/16 Action for Health in Diabetes Extension Study Research Project, General Clinical Research Center, 14/16 Action for Health in Diabetes Extension Study Research Project, 02/16 Action for Health in Diabetes Extension Study Research Study, Harvard Clinical and Translational Science Center (UL1), General Clinical Research Center, General Clinical Research Center, GENERAL CLINICAL RESEARCH CENTER, University of Pittsburgh Clinical and Translational Science Institute, 16/16 Action for Health in Diabetes Extension Study Biostatistics Research Center, 09/16 Action for Health in Diabetes Extension Study Research Project, 08/16 Action for Health in Diabetes Extension Study Research Project, 07/16 Action for Health in Diabetes Extension Study Research Project, 04/16 Action for Health in Diabetes Extension Study Research Project, 03/16 Action for Health in Diabetes Extension Study Research Project, 13/16 Action for Health in Diabetes Extension Study Research Project, 11/16 Action for Health in Diabetes Extension Study Research Project, 15/16 Action for Health in Diabetes Extension Study Research Project, Obesity/Nutrition Research Center, 12/16 Action for Health in Diabetes Extension Study Research Project, 06/16 Action for Health in Diabetes Extension Study Research Project, Colorado Nutrition Obesity Research Center, G955307958
OpenAlex ID: W4206523504