Work

Associations Between Autoimmune Conditions and Gastric Cancer Risk Among Elderly Adults in the United States

Year: 2021

Type: article

Abstract: INTRODUCTION: Pernicious anemia (PA) is a risk factor for gastric cancer. Other autoimmune conditions may also contribute. METHODS: In a case-control study, we evaluated 47 autoimmune conditions among 39,125 gastric cancers and 200,000 cancer-free controls. RESULTS: Six conditions were associated with increased gastric cancer risk (range of adjusted odds ratios: 1.28-1.93, P < 0.05): PA, membranous nephropathy, primary biliary cirrhosis, pure red cell aplasia, primary sclerosing cholangitis, and Graves disease. PA was associated with 8 other autoimmune conditions (adjusted odds ratios: 1.57-4.54, P < 0.05). DISCUSSION: Autoimmune conditions associated with gastric cancer or PA may reflect effects of autoimmune gastritis or other carcinogenic pathways.

Source: The American Journal of Gastroenterology

DOI: 10.14309/ajg.0000000000001622

Authors: Minkyo Song, M. Constanza Camargo, Andriy Derkach, Charles S. Rabkin, Eric A. Engels

Institutions: National Institutes of Health, Division of Cancer Epidemiology and Genetics

Language: English

Topic: Helicobacter pylori-related gastroenterology studies

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute