Work

Spherical and rod shaped mesoporous silica nanoparticles for cancer-targeted and photosensitizer delivery in photodynamic therapy

Year: 2022

Type: article

Abstract: -glycoside porphyrins (Pors). The ensuing nanomaterials were fully characterized, and their properties as third-generation PSs for PDT against two bladder cancer cell lines, HT-1376 and UM-UC-3, were examined. The best uptake results were obtained for MSNP-PS2, while MSNP-PS1 showed the lowest cellular uptake among the nanocarriers tested, but revealed the best phototoxicity in both cancer cells. Overall, the phototoxicity was higher with MSNPs than with mesoporous silica nanorods (MSNRs) and higher uptake and phototoxicity were consistently observed in UM-UC-3 rather than in HT-1376 cancer cells.

Source: Journal of Materials Chemistry B

DOI: 10.1039/d1tb02299g

Authors: Wioleta Borzęcka, Patrícia M. R. Pereira, Rosa Fernandes, Tito Trindade, Tomás Torres, João P. C. Tomé

Institutions: University of Aveiro, Universidad Autónoma de Madrid, University of Coimbra, Centro de Inovação em Biomedicina e Biotecnologia, Madrid Institute for Advanced Studies, IMDEA Nanoscience, University of Lisbon, Instituto Superior Técnico, Centro de Química Estrutural

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Ministerio de Economía y Competitividad, Fundação para a Ciência e a Tecnologia, FP7 People: Marie-Curie Actions

Awards: G1615063063, Centro de Inovação em Biomedicina e Biotecnologia, G196013823, G2073470282, G2128088618, G2511142707, G2595863301, Centro de Química Estrutural, CICECO-Instituto de Materiais de Aveiro, Centro de Inovação em Biomedicina e Biotecnologia, DESIGN OF NOVEL GALACTO-DENDRITIC-PHOTOSENSITIZERS: SELECTIVELY TARGETING AND KILLING CANCER CELLS, Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos, G982922924

OpenAlex ID: W4206589705

FWCI: 4.393

Cites: 61

Cited by: 36

Related to: 10