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Association Between Cigarette Smoking and Breast Milk Levels of Nesfatin-1, Irisin, and Oxidative Stress Markers

Year: 2021

Type: article

Abstract: Background: Breast milk is a very important functional food in the prevention of metabolic and chronic diseases. This study aimed to investigate the effects of smoking during pregnancy on the concentrations of nesfatin-1, irisin, and oxidative stress markers in breast milk. Methods: This study included two groups of 14 smoking and 14 nonsmoking mothers. Malondialdehyde (MDA) level and superoxide dismutase (SOD) activity were measured according to the spectrophotometric method in breast milk samples. Nesfatin and irisin levels were measured by enzyme-linked immunosorbent assay. Results: Levels of nesfatin-1 and MDA of the smoking group were significantly higher than those in the control group (p < 0.001). The SOD activity of the smoking group was significantly lower than that of the control group (p < 0.001). No significant difference was found in the breast milk irisin level between the study groups (p > 0.050). Conclusions: Cigarette smoking increases MDA level and decreases SOD activity in breast milk. Nesfatin-1 levels would increase in accordance with increased oxidative stress, and nesfatin-1 acts as a protective mechanism to limit oxidative damage.

Source: Makara Journal of Health Research

DOI: 10.7454/msk.v25i3.1294

Authors: Yildiz, Nesibe, Yilmaz, Adnan, Iskender, Hatice, Dokumacioglu, Eda

Institutions: Istanbul University-Cerrahpaşa, Istanbul University, Recep Tayyip Erdoğan University, Artvin Coruh University

Language: English

Topic: Infant Nutrition and Health

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: diamond

OpenAlex ID: W4206598520

FWCI: 0.154

Cites: 33

Cited by: 1

Related to: 10