Year: 2022
Type: article
Abstract: The pharmacology and toxicology of a broad variety of therapies and chemicals have significantly improved with the aid of the increasing in vitro models of complex human tissues. Offering versatile and precise control over the cell population, extracellular matrix (ECM) deposition, dynamic microenvironment, and sophisticated microarchitecture, which is desired for the in vitro modeling of complex tissues, 3D bio-printing is a rapidly growing technology to be employed in the field. In this review, we will discuss the recent advancement of printing techniques and bio-ink sources, which have been spurred on by the increasing demand for modeling tactics and have facilitated the development of the refined tissue models as well as the modeling strategies, followed by a state-of-the-art update on the specialized work on cancer, heart, muscle and liver. In the end, the toxicological modeling strategies, substantial challenges, and future perspectives for 3D printed tissue models were explored.
Source: Archives of Toxicology
Institution: University of California San Diego
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,790
Awards: EAGER: Understanding Nano-Cardio Interactions Using 3D Bioprinted Human Heart Tissue, EAGER: Three-Dimensional Printing of Functional Nanobots for Precision Gene Delivery, G4713028518, G4803769919, G5158239548, G7957186708, 3D Printing of Precision Scaffolds for Volumetric Muscle Tissue Regeneration, G9000013561, G9000222924, G9000323281
OpenAlex ID: W4206710941