Year: 2021
Type: article
Study design: Observational Study
Abstract: Background The role of hippocampal connectivity for good memory performance is well known in persons with high educational level. However, it is understudied the role of hippocampal connectivity in illiterate populations. Methods Thirty‐nine illiterate adults underwent resting state functional MRI and an episodic memory test (Free and Cued Selective Reminding Test). We correlated the hippocampal connectivity at rest with the free recall scores. Analyzes were corrected for head motion and physiological BOLD signal. Results Participants were most female (66%) and black (79%) and the mean age was 49 years‐old (±13.9). The mean score on free recall was 27.2 (±10.7) out of 48 points. We found a significant correlation between the hippocampus and the right parahippocampal gyrus, right insula and right basal ganglia. However, we did not find an association between the hippocampal connectivity and the memory scores. Conclusions Illiterate adults have a significant correlation between the hippocampus and the right insula and basal ganglia. The lack of association with memory scores might be associated with low brain reserve in this group of individuals.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.051877
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4206713643