Work

Structure-based design, synthesis and biological evaluation of aminopyrazines as highly potent, selective, and cellularly active allosteric SHP2 inhibitors

Year: 2022

Type: article

Source: European Journal of Medicinal Chemistry

DOI: 10.1016/j.ejmech.2022.114106

Authors: Kai Tang, Min Zhao, Ya-Hong Wu, Qiong Wu, Shu Wang, Yu Dong, Bin Yu, Yihui Song, Hong-Min Liu

Institution: Zhengzhou University

Language: English

Topic: Protein Tyrosine Phosphatases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, Science and Technology Innovation Talents in Universities of Henan Province

Awards: G1186655664, G1441778411, G1834374550, G8130012984, G930825416

OpenAlex ID: W4206740821

FWCI: 1.177

Cites: 63

Cited by: 20

Related to: 10