Vaccine effectiveness against COVID‐19 among symptomatic persons aged ≥12 years with reported contact with COVID‐19 cases, February–September 2021
Year: 2022
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Individuals in contact with persons with COVID-19 are at high risk of developing COVID-19; protection offered by COVID-19 vaccines in the context of known exposure is poorly understood. METHODS: Symptomatic outpatients aged ≥12 years reporting acute onset of COVID-19-like illness and tested for SARS-CoV-2 between February 1 and September 30, 2021 were enrolled. Participants were stratified by self-report of having known contact with a COVID-19 case in the 14 days prior to illness onset. Vaccine effectiveness was evaluated using the test-negative study design and multivariable logistic regression. RESULTS: Among 2229 participants, 283/451 (63%) of those reporting contact and 331/1778 (19%) without known contact tested SARS-CoV-2-positive. Adjusted vaccine effectiveness was 71% (95% confidence interval [CI], 49%-83%) among fully vaccinated participants reporting a known contact versus 80% (95% CI, 72%-86%) among those with no known contact (p-value for interaction = 0.2). CONCLUSIONS: This study contributes to growing evidence of the benefits of vaccinations in preventing COVID-19 and support vaccination recommendations and the importance of efforts to increase vaccination coverage.
DOI: 10.1111/irv.12973
Authors: Jessie R Chung, Sara S Kim, Edward A Belongia, Huong Q McLean, Jennifer P King, Mary Patricia Nowalk, Richard K Zimmerman, Krissy Moehling Geffel, Emily T Martin, Arnold S Monto, Lois E Lamerato, Manjusha Gaglani, Eric Hoffman, Marcus Volz, Michael L Jackson, Lisa A Jackson, Manish M Patel, Brendan Flannery
Institutions: Centers for Disease Control and Prevention, Marshfield Clinic Research Foundation, Marshfield Clinic Research Institute, University of Pittsburgh, University of Pittsburgh Medical Center, University of Michigan, Henry Ford Health, Baylor Scott & White Health, Texas A&M University, Kaiser Permanente Washington Health Research Institute
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,000
Funders: Washington Research Institute, Kaiser Permanente, University of Michigan, Henry Ford Health System, University of Pittsburgh, Marshfield Clinic Research Institute, Baylor Scott and White Health, National Institutes of Health, Centers for Disease Control and Prevention, Medical Center, University of Pittsburgh, National Center for Immunization and Respiratory Diseases, National Center for Advancing Translational Sciences
Awards: G173032220, ANNUAL ESTIMATES OF INFLUENZA VACCINE EFFECTIVENESS AND EVALUATION OF IMMUNE RESPONSE IN A WISCONSIN POPULATION, G2990523770, G5263438135, G5302373467, PROSPECTIVE ANNUAL ESTIMATES OF INFLUENZA VACCINE EFFECTIVENESS AND BURDEN OF DISEASE, US INFLUENZA VACCINE EFFECTIVENESS NETWORK, OUTPATIENT VE FOR SEASONAL FLU, PANDEMIC FLU AND RSV IN A LARGE, DIVERSE NETWORK, G8298702375, G846102573, G8548161866, MANDATORY_ESTIMATES OF VACCINE EFFECTIVENESS AGAINST MEDICALLY-ATTENDED, PCR-CONFIRMED INFLUENZA IN WEST SOUTH CENTRAL U.S., University of Pittsburgh Clinical and Translational Science Institute
OpenAlex ID: W4212896891