Work

Gene Expression and In Vitro Pharmacogenetic Studies of Dopamine and Serotonin Gene Receptors in Tuberculosis.

Year: 2021

Type: article

Abstract: BACKGROUND: Dopamine and serotonin receptors are present in lymphocytes, macrophages, and neutrophils, and have a mediating role in the immune system to respond to infections, including bacterial tuberculosis. MATERIALS AND METHODS: (H37RV) were performed. Stimulation of the pro-inflammatory pathway by secreting cytokines before and after drug efficacy was investigated. RESULTS: According to the result, dopamine receptor 2 genes showed decreased expression in patients with tuberculosis compared to normal individuals, and serotonin receptor genes showed increased expression. Additionally, with the effects of Bromocriptine and Fluoxetine, pro-inflammatory pathways were activated in macrophages infected with H37RV, and ELISA results showed that the levels of IL6 and TNFα secreted in these cells were significantly increased. CONCLUSION: According to the results, these receptors agonists or antagonists can activate the autophagy pathway to kill TB bacteria.

Source: PubMed

Authors: Mojgan Sheikhpour, Mohammad Ali Shokrgozar, Alireza Biglari, Majid Pornour, Farid Abdolrahimi, Shahin Poorazar Dizaji, Sharareh Khanipour, Morteza Masoumi, Nayereh Ebrahimzadeh, Hanieh Abolfathi

Institutions: Pasteur Institute of Iran, University of Zanjan, Academic Center for Education, Culture and Research

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4206851763

FWCI: 0.17

Cites: 25

Cited by: 7

Related to: 10