Work

Translational Role of Rodent Models to Study Ventilator-Induced Lung Injury.

Year: 2021

Type: article

Abstract: Mechanical ventilation is an important part of medical care in intensive care units and operating rooms to support respiration. While it is a critical component of medical care, it is well known that mechanical ventilation itself can be injurious to the lungs. Despite a large number of clinical and preclinical studies that have been done so far, there still exists a gap of knowledge regarding how to ventilate patients mechanically without increasing lung injury. Here, we will review what we have learned so far from preclinical and clinical studies and consider how to use preclinical models of ventilation-induced lung injury that better recapitulate the clinical scenarios.

Source: PubMed

Authors: Koichi Yuki, Sophia Koutsogiannaki

Institutions: Boston Children's Hospital, Harvard University

Language: English

Topic: Respiratory Support and Mechanisms

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of Allergy and Infectious Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: Neutrophil-mediated multiple organ dysfunction during sepsis, Optimization of anesthetic/sedative regimen for pulmonary pathophysiology in cystic fibrosis patients