Work

Curcumin slows the progression of Alzheimer's disease by modulating mitochondrial stress responses via JMJD3-H3K27me3-BDNF axis.

Year: 2021

Type: article

Abstract: cellular models of AD, up-regulation of either JMJD3 or BDNF up-regulated BDNF levels, down-regulated H3K27me3 methylation levels, mitigated abnormalities of MSR markers and Aβ aggregation, and increased cell proliferation and inhibited apoptosis. JMJD3 was confirmed to regulate Aβ and MSR via BDNF. In addition, CUR was confirmed to modulate JMJD3-H3K27me3-BDNF axis. Furthermore, moderate and high doses of CUR could improve the morphology and histopathology of the brain, inhibit Aβ aggregation and cell apoptosis, and maintain MSR balance at least partly by modulating the JMJD3-H3K27me3-BDNF axis. To sum up, moderate and high doses of CUR regulate the progression of AD via MSR JMJD3-H3K27me3-BDNF axis.

Source: PubMed

Authors: Jingna Li, Shanshan Wang, Simiao Zhang, Dan Cheng, Xiaopeng Yang, Yutong Wang, Honglei Yin, Yajun Liu, Yanqiu Liu, Hongying Bai, Shuang Geng, Yunliang Wang

Institutions: Zhengzhou University, Second Affiliated Hospital of Zhengzhou University, Qilu Medical University

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4206870258

FWCI: 0.725

Cites: 33

Cited by: 12

Related to: 10