Anatomical Association Between Schizophrenia and Cerebellum.
Year: 2021
Type: article
Study design: Case Report
Abstract: The pathogenesis of schizophrenia is rarely attributed to dysfunction of the cerebellum. However, coordination of mental processes might involve the cerebellum and a cortico-cerebellar-thalamic-cortical circuit (CCTCC) that can mediate that process has been proposed. We present the case of a 31-year-old male patient with a family history of psychosis who developed schizophrenia in association with a slow-growing glioblastoma at the left posterior cerebellar pontine angle. Of interest is that his psychosis became refractory after surgical removal of the tumor that had no motor deficit consequences, suggesting that the greater disruption of the CCTCC due to surgical excision might be related to the worsening psychosis. The case supports the hypothesis of cognitive dysmetria and psychosis.
Source: PubMed
Authors: Rajashekar Reddy Yeruva, Yafei Shang, Ben Schoenbachler, Sharon Nuss, Rif S El-Mallakh
Institutions: University of Louisville, Baylor Scott & White Health
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4206883222