Work

Targeting the oncogenic TBX3:nucleolin complex to treat multiple sarcoma subtypes.

Year: 2021

Type: article

Abstract: ). Our findings provide the first evidence that TBX3 requires nucleolin to promote features of sarcomagenesis and that disruption of the oncogenic TBX3-nucleolin interaction by AS1411 may be a novel approach for treating sarcomas.

Source: PubMed Central

Authors: Tarryn Willmer, Victoria Damerell, Shannon Smyly, Danica Sims, Michelle Du Toit, Stephanie Ncube, Musalula Sinkala, Dhirendra Govender, Edward Sturrock, Jonathan M Blackburn, Sharon Prince

Institutions: South African Medical Research Council, University of Cape Town, Stellenbosch University, Institute of Infectious Disease and Molecular Medicine, Groote Schuur Hospital

Language: English

Topic: Sarcoma Diagnosis and Treatment

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4206896459

FWCI: 0.9

Cites:

Cited by: 11

Related to: 10