Author response: Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness
Year: 2021
Type: peer-review
Abstract: Plasmodium falciparum K13 mutations confer resistance to the antimalarial artemisinin in Asian and African parasites, with most gene-edited mutant K13 African parasite lines showing a fitness cost that may predict slow dissemination of artemisinin resistance in high-transmission settings.
Source: eLife
Authors: Barbara H Stokes, Satish K Dhingra, Kelly Rubiano, Sachel Mok, Judith Straimer, Nina F Gnädig, Ioanna Deni, Kyra A Schindler, Jade R Bath, Kurt E Ward, Josefine Striepen, Tomas Yeo, Leila S Ross, Eric Legrand, Frédéric Ariey, Clark H Cunningham, Issa M Souleymane, Adama Gansané, Romaric Nzoumbou-Boko, Claudette Ndayikunda, Abdunoor M Kabanywanyi, Aline Uwimana, Samuel J Smith, Olimatou Kolley, Mathieu Ndounga, Marian Warsame, Rithea Leang, François Nosten, Timothy JC Anderson, Philip J Rosenthal, Didier Ménard, David A Fidock
Institutions: Columbia University Irving Medical Center, University of Otago, Centre National de la Recherche Scientifique, Inserm, Institut Pasteur, Institut Cochin, Université Paris Descartes, University of North Carolina at Chapel Hill, Chad National Malaria Control Programme, Centre National de Recherche et de Formation sur le Paludisme, Institut Pasteur de Bangui, Ifakara Health Institute, Rwanda Biomedical Center, Programme National de Lutte contre le Paludisme Togo, University of Gothenburg, Cambodia National Malaria Center, Mahidol University, University of Oxford, Shoklo Malaria Research Unit, Mahidol Oxford Tropical Medicine Research Unit, Texas Biomedical Research Institute, University of California, San Francisco
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,500
OpenAlex ID: W4207008169